Endocrine Abstracts

Diabetes is a chronic disease whose associated comorbidities are largely influenced not only by pathology but also by socio-economic conditions. The aim of this study is to investigate the influence of social conditions on the evolution of diabetes. A retrospective, comparative study of 111 patients with type 2 diabetes Follow-up in the Endocrinology-Diabetology department in hospital Hedi Chaker of Sfax. Patients were divided into two groups with unfavorable (G1) and good (G2...

Introduction: Thyroid dyshormonogenesis (TD) accounts for 15–20% of congenital hypothyroidism (CH). Levothyroxine is the treatment of choice with the immediate goal to raise the serum T4 as rapidly as possible. Surgical treatment is indicated in case of compressive or suspected goiter.Patients and methods: Seventeen patients with thyroid dyshormonogenesis belonging to 4 Tunisian families were included in a descriptive prospective study. They were fo...

Introduction: Adrenal cystic lesions are uncommon and mostly identified incidentally during radiological investigations or at surgery for unrelated reasons. Its incidence varies between 0.064 and 0.18%. Adrenal cysts are classified as endothelial cysts, pseudocysts, epithelial cysts, and parasitic cysts.Case report: A 45-year-old female with a past medical history of systemic hypertensive disease for 2 years, presented with recurrent abdominal pain durin...

Introduction: Pituitary apoplexy (PA) is a rare incident defined by the occurrence of necrosis and/or haemorrhage of the pituitary gland. The low incidence of PA makes it difficult to bring out from the studies its precipitating factors and especially its relationship with cardiovascular risk factors (CVR). The objectives of this studies were to characterize a number of patients with PA and to establish the link between PA and their CVRs.Methods: It is a...

Introduction: Extra-adrenal paragangliomas are neoplasms arising from cells of neural crest origin anywhere along the distribution of the sympathoadrenal neuroendocrine system. Nearly 85% are intra-abdominal, 12% are intrathoracic, and 3% are cervical. 1 Some of the unusual sites for paragangliomas include the kidney, urethra, urinary bladder, prostate.Case report: A 27-year old man presented with sever hypertensive crisis. He had a medical history of hi...

Introduction: Congenital adrenal hyperplasia (CAH) is a genetic disease with autosomal recessive inheritance. The deficit in 21-hydroxylase (21-OH) is by far the most common enzyme deficiency CAH, since it represents 95% of the cases. Fertility in wome is found to be reduced due to hormonal, mechanical and psychological factors.Patients and methods: It is about a descriptive and prospective study conducted in 15 patients collected in the endocrinology de...

Introduction: In Tunisia, only about 10% of people with diabetes practice self-injecting insulin analogues. It is 1 Tunisian adult out of 11 who is affected directly by diabetes. Our goal is to assess diabetes patients’ knowledge of insulin injection techniques.Patients and methods: Prospective study of 56 cases of type 2 diabetic patients in the Endocrinology Department CHU Hedi Chaker Sfax Tunisia. All patients had a questionnaire and clinical exa...

Obesity is considered as an exceeding life style disorder notably in developing countries and it is prevailing at a frightful speed in new world countries as a result of fast food intake, causing raised blood cholesterol levels, which in turn can damage many systems in the body. The present study investigates the hypolipidemic effects of sulphated polysaccharide obtained from Codium fragile (CFSP) in induced obese rats (HFD). The results showed an increase in body weight of HF...

Leptin (LEP) gene is one of the most promising candidate genes for obesity. The aim of this study was to investigate the impact of LEP polymorphisms on obesity, anthropometric and biochemical parameters in a sample of three Tunisian consanguineous families with obesity. Seven single nucleotide polymorphisms (SNPs) in 5′ region of LEP gene were genotyped in three consanguineous families including 33 individuals. The previously reported LEP</...

Introduction: Pituitary abscesses are rare entities that can occur either as primary infections or secondarily to different causes. Primary pituitary abscess arises within a previously healthy gland, while secondary abscess occurs in pituitary gland that harbors a pre-existing lesion (adenoma, craniopharyngioma, or Rathke’s cleft cyst). Only 23 cases of secondarily infected adenomas were reported in the literature.Case report: A 38-years-old man pre...